A Q About Resistance And Tolerance, is There a Good Def. of Each of These?

Question

Is Resistance On a Cellular Level, Whereas Tolerance is On a Multi-Cellular Level?

Answer 1

Not really.  Both actually take place and can be explained on a molecular/cellular level, which then translates to the multi-cellular/organism level.  Strictly speaking, resistance means just that.  The cell/organ/species does not react to a given drug or compound.  It is resistant, and no matter how much drug or compound you expose it to, it does not react.  Tolerance is somewhat different in that it means that it takes more drug/compound to achieve the same effect as that which was seen prior to the development of tolerance.  Tolerance is also "endpoint specific".  That is to say, e.g. a person could become tolerant to the sedative effects of alcholo, but not to some other effects of alcohol. Depends on the end point you are measuring.

Answer 2

Don't know much about cells, but I do know that resisting pain makes it more difficult to tolerate.    If you put your nose to the rough bark of a tree, it dominates your consciousness - but if you step back you can see the forest.   Ultimately, after all, it's all in the mind.   My Grandpa taught me that, with the point of a knife.