A question on Human Genetics to test your knowledge!?

Question

The proliferation of cytotoxic T-Cells is markedly impaired upon infection with a newly discovered HIV virus (HIV - V). The defect has been traced to the expression of a viral encoded enzyme that inactivates a host cell nuclear protein required for DNA replication. Which protein is a potential substrate for the viral enzyme.?

A - TATA - box binding protein (TBP)

B - Cap binding protein (CBP)

C - Catabolite activator protein ( CAP)

D - Acyl-carrier protein (ACP)

E - Single strand binding protein (SBP)

Answer 1

E....I chose this answer because after looking at the options, this to me would be the best choice of gaining me firstly 2 points and then hopefully 10 points if you were to choose my answer as the top answer, because lets face it how many other serious answers are you going to get to this question?

Answer 2

The explanation:

Lab rat is right about the answer- E is the one involved in DNA replication. You are given that the viral enzyme inactivates a host protein important for DNA replication. DNA replication is necessary for T-cell proliferation (multiplication). Therefore, the HIV virus inactivates SBP, and the T cells subsequently can't proliferate.

Answer 3

I vote for E as single stranded binding protein is involved with cell DNA replication but the others aren't, although I guess CBP might be involved in early gene activation in the cell cycle and appears to have some role in epigenetic regulation of genes in general. But everything else justs seems to be involved in transcription etc

Answer 4

E - the only one directly involved in DNA replication.  

Answer 5

Highly technical. You may do your own homework.

Answer 6

Are you trying to impress us with your knowledge because I doubt you'll get many answers.