I've got a computer with only 80Gb hard drive, and i've been gradually replacing bits and pieces like RAM, so i thought the hard drive should be next considering i've got a few gigabytes free. Other questions seem to hint that i can do it, although applications will only work on the computer they were installed on due to registry information, but i just wanted some definite answer, instead of buying it and realising that my applications (which take up 90% of my HDD) can't be installed on it.
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