Can I use poisonous plants like Jetropha Curcas or Calotropis Gigantea in my compost pile?

Question

Will it have any adverse effect on microbs?

Answer 1

Yes.

Their poison has nothing to do with affecting microbes.

Answer 2

Yes you can. The toxins that affect higher animals (vertebrates) usually don't affect microbes. If your compost pile is large enough and diverse enough, it will break down quickly.