Can i use my U.S. visa flying from a different place where it was issued?

Question

I'm an immigrant in Italy. Now I'm planning back to go back to my country. I was given a 10-year tourist visa by the US embassy in Rome and I've been to the States several times since 2004. Is it possible for me to use the visa even if my port of entry is not anymore Rome?

Answer 1

Of course you may use it to travel to the US.  The visa allows you to seek permission to enter the US - it does not stipulate a point of departure or a US port of entry.

Answer 2

Absolutely no problems, except Canada/USA/Canada.