Can the typhoid oral vaccine survive 25 min out of refrigeration?

Question

The Vivotif Berna Typhoid Vaccine Live Oral Ty21a is supposed to be refrigerated [2ºC - 8ºC (35.6ºF - 46.4ºF)] "at all times" between doses, according to the instructions. Does anyone know if it possible for the live vaccine to survive 25 minutes out of refrigeration?

Answer 1

All vaccines that require a cold chain say "at all times". Leaving a vaccine out for a short amount of time will not ruin the efficacy of the vaccine. I suggest using an ice chest, if the issue is transport. I always use a soft lunch cooler and fill it with ice for anything that is typically kept at 4C.