Celiac disease and heredity ?

Question

What are the chances that a woman with Celiac Disease will pass it on to her children?

(Please include sources)

Answer 1

Ruby,

An additional seven gene regions have been identified that are linked to coeliac disease. Additionally, of the nine coeliac associated gene regions now known, four also predispose a patient to type 1 diabetes. This research marks a step forward in the understanding of coeliac disease as well as the origins of diabetes, and was published on March 2, 2008 in Nature Genetics. David van Heel, Professor of Gastrointestinal Genetics at Barts and The London School of Medicine and Dentistry, led a team that last year identified a new genetic risk factor for coeliac disease. Continuing this research, they collaborated with researchers in Ireland, the Netherlands, and the Wellcome Trust Sanger Institute to learn more about more hereditary factors contributing to the disease. They began by performing a genome wide association study, comparing genetic markers across the genome in coeliac disease subjects to healthy controls. Focusing on 1,000 of the strongest markers, they identified seven new regions associated with risk of the disease. Six of these specifically hold genes that are critical to control of the immune response, which reinforces their significance in the disease's development.

Professor van Heel states that this is a major movement forward in the understanding of coeliac disease: "So far our findings explain nearly half of the heritability of coeliac disease - now studies with many more samples from individuals with coeliac disease are needed to identify the precise causal genetic variants from each region, and understand how these influence biological processes."

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I add a link with further details of this subject

http://www.seekwellness.com/

nutrition/celiac_disease.htm

Hope this helps

matador 89