MCPH1 is not evenly distributed across the globe. It occurs most often in European, East Asian, and certain South American Indian populations, and is least common in sub-Saharan Africans.
Nontonal language:
The presence of MCPH1 in a population correlate to that population using a nontonal language.[4] For example, tonal languages are common in sub-Saharan Africa, where MCPH1 is scarce. The presence of a recent ASPM allele also correlates to nontonal language.
Hypothetical origin
MCPH1 "regulates brain size during development and has experienced positive selection in the lineage leading to Homo sapiens." "Within modern humans, a group of closely related haplotypes at this locus, known as haplogroup D, rose from a single copy approx 37,000 years ago and swept to exceptionally high frequency (approx 70% worldwide today) because of positive selection. [...] Haplogroup D likely originated from a lineage separated from modern humans approx 1.1 million years ago.
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