Does SPIRONOLACTONE / ALDACTONE contain progestin?

Question

umm anyone knows?

don't just link me to spironolactone/aldactone page that don't even have the word progestin in them please >.<

thanks !

Answer 1

I believe that A Simple Man has offered you a cogent answer to your question and thus I&#039;m certain that he does, indeed, know.

Answer 2

Spironolactone is very simular to progesterone, chemically. There is only a few differences when you look at the molecules. See:

http://www.thebestlinks.com/images/thumb...

http://userwww.service.emory.edu/~rherma...

But the hormonal effect are different.

Spironolactone does indeed have progestational (like progesterone) effects but not much. Its main effect is as an Anti-mineralocorticoid (affecting the kidney). It also has Anti-androgenic (blocking androgens) effects. That is why it helps to grow back hair.

Answer 3

No, spironolactone/Aldactone pills contain only one chemical -- spironolactone.

Spironolactone works by inhibiting aldosterone, which is a naturally-occuring steroid-based hormone responsible for water/mineral regulation in the kidneys.  This is why the main use of spironoactone is as a diuretic (&quot;water pill&quot;), which makes people pee more.

Unfortunately, our body uses steroid-based hormones for many different bodily functions.  And since all these hormones are all based on the steroid molecule (4 rings, 3 of which are 6-sided, and one five-sided), they look very much alike.

Steroid: http://en.wikipedia.org/wiki/Steroid

Aldosterone (hormone in charge of water/mineral regulation): http://en.wikipedia.org/wiki/Image:Aldos...

Dihydro-testosterone (an androgen, which is a male s*x hormone): http://en.wikipedia.org/wiki/Dihydrotest...

Because of their structural similarity, spironolactone not only inhibits aldosterone, it also inhibits dihydro-testosterone, a male s*x hormone.

As a result, spironolactone causes &quot;feminizing&quot; side effects such as gynecomastia (enlargement of b*****s), menstrual irregularities and testicular atrophy.  This is probably why some people mistakenly conclude that spironolactone contains female s*x hormones (such as progestin), when it absolutely does not.

Hope that helps.

Answer 4

I don&#039;t believe so. Drospirenone is the progestin analog of Aldactone.