Does dopamine in the NAc facilitate or impair medium spiny neuron firing?

Question

All I can find is that it "modulates." I know it depends on whether we;re dealing wth D1 or D2, but in the big picture:

The GABAergic MSNs of the nucleus accumbens (NAc) fire when they get enough glutamatergic stimulation. Does the presence of DA in the NAc (as in the case of cocaine stimulation) reduce the amount of glutamatergic stimulation needed to make them fire (ie, facilitate transmission) or increase the amount needed (ie, impair transmission)?

Best answer to a well-cited response!!

Thanks.

Answer 1

using http://books.google.com/books?id=bk4IPCp...

Pages 106-108 text and drawings

The American Psychiatric Publishing

textbook of schizophrenia

By Jeffrey A. Lieberman

, T. Scott Stroup

, Diana O. Perkins

, American Psychiatric

Publishing, American

Psychiatric Publishing

Published 2006

Seems to answer your question

.. too much to copy here