Does kidney failure necessarily mean the body is in metabolic acidosis?

Question

Does kidney failure necessarily mean the body is in metabolic acidosis?

Answer 1

Yes. Bilateral renal failure if untreated keeps  the body acidotic.

Answer 2

Yup, the kidneys provide the strongest influence on the body's pH levels due to their excretion of H+ and formation of bicarbonate (HCO3).  If the kidneys fail, then the H+ in your body will build up, and what's worse is that no HCO3 is being formed to act as a buffer to counteract the rise H+ levels.

For a short term fix, your body will start increasing its rate of breathing, but that can't be maintained.

Answer 3

Yes.

Kidney failure  Ã¢Â†Â’ Lesions in Renal Tubular Epithelial Cells → Excrete NH3、H+↓ → Producing HCO3- ↓ → Metabolic acidosis