Does the supplement Sam E work?

Question

I picked up a bottle at the store because it says it helps with moodiness. Has anyone tried this? If so, could you tell a difference?

Answer 1

After 3-4 wks of taking it daily, I definitely noticed an improvement (major depression) & I was a skeptic (but desperate) - had 2 stop coz it was 2 xpensive ! Now use Marijuana which works faster & better (when I can get it !!!)

Answer 2

Since it's discovery in 1952, S-Adenosyl methionine (better known as SAM-e) has been the subject of numerous clinical trials.  According to the Agency for Healthcare Research and Quality (U.S. Department of Health and Human Services) it is effective in the treatment of depression.