Enzymy kind of Question?

Question

Why is it necessary for enzymes such as trypsin and pepsin to be secreted into the body in an inactive form?

I cant find the answer anywhere and hope someone can help.

Thanks.

Answer 1

trypsinogen. chymotrpsinogen are inactive enzymes precursors activated by enterokinase(enteropeptidase), an enzyme in the microvilli, which converts then into active proteolytic enzymes trysin and chymotrypsin. it is very important that these are produced in  active form and are activated only upon arrival in the duodenum, otherwise they would digest the pancreas.....

Answer 2

Trypsin and pepsin are proteases and if produced in an active form they would digest the cells where they are formed.

They are activated in the small intestine and stomach respectively.

Hope this helps!

Answer 3

they're protein degrading proteins. they're released into the stomach in inactive form due to their harmful effects if they are released in active form. it would eat at your stomach lining.

Answer 4

They are strong enzymes, but due to the large amount of food (sustrates) eaten at any one given time, they are needed in large quantities with the ability to be turned on and off when needed. Most of the time when you see the zymogen (inactive form of an enzyme) you can think of it as on stand by, or on the bench ready to spring into action when needed.