Friend has irritable leg syndrome, now calf and knee pain with charly horse in feet?

Question

He has been on leg medicine for several years and the severity of the calf and knee pain is increasing. He has prior neck and back injuries.

Answer 1

There are several possibilities for what could be causing this such as a more serious problem with the digestive tract such as Crohn's (an example only).  In some conditions such as Crohn's symptoms can affect the legs and knees.

I would recommend that he get back in touch with his doctor for further evaluation of the situation to see what they say.