Question:

Glycolysis, choose the statement that would follow?

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A. occurs in the mitochondria

B. results in the production of pyruvate

C. occurs in the cytoplasm

D. occurs in the mitochondria and results in the production of pyruvate

E. results in the production of pyruvate and occurs in the cytoplasm

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  1. E). results in the production of pyruvate and occurs in the cytoplasm.


  2. The correct answer is E. The 10 steps of the glycolytic pathway occur in the cytoplasm and the result is production of pyruvate. Under anaeroic conditions such as in white muscle, the pyruvate is converted to lactate ( to recycle NAD+ for use by glycolysis ) and the lactate is sent to the liver where it is reconverted to glucose via the Cori Cycle.

    In aerobic tissues, glycolysis ( which does NOT require O2 ) still produces pyruvate but in  this case the pyruvate will enter the mitochondrion and be converted to acetyl CoA so it can enter the Kreb's TCA cycle. The NAD+ is recycled by the use of shuttles which are intimately associated with the mitochondrion .

  3. E

  4. E.  Glycolysis occurs in the cytoplasm and results in the production of pyruvate, in addition to a net of two ATP molecules.  It can occur anaerobically.  Further breakdown of the pyruvate (eventually into carbon dioxide and water) occurs in the Krebs cycle, in the mitochondria.  This portion requires oxygen to occur (thus, it is aerobic).

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