Hard drive problem. Hi I have an e machine PC and i was having problems with my PC recognizing its

Question

Hi I have an e machine PC and i was having problems with my PC recognizing its hard drive so I took the hard drive out and placed it in another PC and it still did not recognize the drive. Is something wrong with my mother board. Is there anything I can do to save my PC? I have everything saved on that Hard Drive and I cannot access it..Please help