Hello! do u know the p53 thing leading to cancer?

Question

its a chain like events which im so confused about!

p53>p27?gadd45 so on!

omg so confusing!

and please include the links too if u knw

thanks!!

Answer 1

p53 is called the apoptosis pathway, which is sucidide cell death. It is a sequence of molecular pathways that results is cells death.

With cancer, this pathway does not work right. Usually the initiation of p53 has problems. When the cell cannot commit apoptosis, then this a growing damaged cell.

I gave you a few links below, hope this helps.

I will include a link because it gets confusing without a picture:

Some of the links will be papers:

http://cancerres.aacrjournals.org/cgi/co...

http://www.pubmedcentral.nih.gov/article...

http://mcb.asm.org/cgi/content/abstract/...

http://www.bioinformatics.org/p53/gif/in...

http://www.bioinformatics.org/p53/introd...

http://www.eurekah.com/pietenpol/03.gif

good luck.