Help physiology?

Question

In a laboratory experiment, adding curare, which binds to acetylcholine receptors, to the solution around a muscle decreases the size of the end plate potential. Adding prostigmine, an acetylcholinesterase blocker, increases the size of the end plate potential. Explain why. (4pts)

Answer 1

Curare blocks the receptors and thus prevents the Na channels from opening and generating depolarisation of the sarcolemma and hence a lower end plate potential results.

Prostigmine results in an accumulation of acetylcholine and hence an increased stimulation of the receptors.