Help with a question concerning metabolic pathways?

Question

"Instructions for manufacturing enzymes are coded in DNA. As enzymes carry out their jobs, even in complex metabolic pathways, they don't need to ask the DNA for further instructions. Where are the operating instructions stored?"

Thanks.

Answer 1

The enzymes can do their jobs because of the immense amount of design and specificity that went into making them and all other parts of the system. Look at this chart

http://www.colby.edu/chemistry/BC368/met...

All of the points on this chart are complicated specific proteins in the form of specific enzymes, molecular machines (ion driven motors, pumps, transport machines, gates, switches, and chemical to physical energy converters... and plenty more - I'm pretty ignorant) and chemical pathways. The amount of information to keep this system running smooth is enormous. The information in DNA does hundreds of thousands of other complicated tasks. This metabolic pathway is just one system in an organism made up of hundreds if not thousands of equally complicated systems.

To think that this was the result of an accident stretches credulity.  

Answer 2

An enzyme simply catalyses the reaction(s) it is suited for, usually each enzyme catalyses one reaction, guided by the interactions between it and the substrate molecule(s) as determined by their shape and the electrostatic charges found on them. There is no need for operating instructions. After all DNA only instructs for the formation of proteins through mRNA.