Thanks for you answers so far.
Allow me to clarify some details:
The basement is a finished living space approx. 1500 sqft. The register vents are located overhead (in the ceiling pointed down), adjusted to the closed damper position and already covered with the typically available magnetic sheet.
Significant cold air flow still occurs, sealing the vents with tape and cardboard, as mentioned, may totally block the flow and force more cool air to the upper level, but will the increased pressure of creating a close to air-tight seal on multiple vents in the basement damage the HVAC system?
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