How could you synthesis Acarbose ?

Question

How could you synthesis Acarbose ?

Answer 1

Acarbose is an anti-diabetic drug used to treat type 2 diabetes mellitus.  It is sold in the USA from Bayer as PRECOSE®.

Originally extracted from fungi or plants, the synthesis of these kinds of drugs are covered by US Patents.  There are several analogs made synthetically.

If your interest is for study, the most details can be found in the US Patent for Precose.  I could not find this on-line, but did find an article about the synthesis of analogs (see below) and references to professional journals.

This is not easy bathtub or kitchen chemistry.