How did the drug Premarin come about ?

Question

I am doing a research assignment on Premarin and am struggling to find any information on how it came about .

I have found that scientists first discovered that they could extract estrogens from the urine of pregnant women back in the 1920's (for therapeutics). They then found that women and horse (mare) urine was very similar so started to extract estrogens from mare urine instead .

Does anybody have any more information about the origins of this drug or any hormone replacement therapy relating to Premarin ?

Thanks

Answer 1

Yes, the word Premarin comes from "Pregnant mares urine".

now it is synthetically made.