How do Psilocybin mushrooms affect your brain in the long run?

Question

How do Psilocybin mushrooms affect your brain in the long run?

Answer 1

if you only do them every now and again you should be okay but heavy use is basicly the same as LSD you can start to feel detached. besides it best to wait a few days at least to get rid of that annoying tolerance

this site has all the info you will ever need

erowid.org

Answer 2

Psilocybin is structurally similar to serotonin, and produces its effects by disrupting normal functioning of the serotonin system.

Some mushroom users experience "flashbacks", or hallucinogen persisting perception disorder (HPPD), which are reoccurrences of hallucinations long after ingesting the drug. The causes of these effects, which in some users occur after a single experience with the drug, are not known.

Answer 3

Well, it's hard to answer your question in few words.

Psilocybin is absorbed through the lining of the mouth and stomach. Effects begin 10–40 minutes after ingestion of psilocybin-containing mushrooms, and last from 2–6 hours depending on dose, species, and individual metabolism. A typical recreational dosage is from 10–50 mg psilocybin.

The effects of psilocybin are highly variable, and dependent on the current mood and overall sense of well-being by the individual. Initially the subject may begin to feel somewhat disorientated, lethargic, and euphoric or sometimes depressed. At low doses, hallucinatory effects may occur, including enhancement of colors and the animation of geometric shapes. Closed-eye visuals may occur, where the affected individual may see multi-coloured geometric shapes and vivid imaginative sequences. At higher doses, hallucinatory effects increase and experiences tend to be less social and more introspectic or entheogenic. Open-eye visuals are more common, and may be very detailed although rarely confused with reality.

Users having a pleasant experience may feel ecstatic, including a deep sense of connection to others, confusion, hilarity, and a general feeling of connection to nature and the universe. Difficult experiences or bad trips may occur in some individuals, often when consumed during emotional turmoil, in a non-supportive or inadequate environment, by an inexperienced person, or in an unexpectedly high dose. Latent psychological issues may be triggered by the strong emotional components of the experience.

Some of these individuals report that they have experienced a 'spiritual' episode. For example, in the Marsh Chapel Experiment, which was run by a graduate student at Harvard Divinity School under the supervision of Timothy Leary, almost all of the graduate degree divinity student volunteers who received psilocybin reported profound religious experiences.

In 2006, a group of researchers from Johns Hopkins School of Medicine led by Roland R Griffiths conducted an experiment assessing the degree of mystical experience and attitudinal effects of the psilocybin experience; this report was published in the journal Psychopharmacology. Thirty-six volunteers without prior experience with hallucinogens were given psilocybin and methylphenidate (Ritalin) in separate sessions, the methylphenidate sessions serving as a control and psychoactive placebo; the tests were double-blind. The degree of mystical experience was measured using a questionnaire on mystical experience developed by Ralph W Hood; 61% of subjects reported a "complete mystical experience" after their psilocybin session, while only 13% reported such an outcome after their experience with methylphenidate. Two months after taking psilocybin, 79% of the participants reported moderately to greatly increased life satisfaction and sense of well-being. About 36% of participants also had a strong to extreme “experience of fear” or dysphoria (i.e., a “bad trip”) at some point during the psilocybin session (which was not reported by any subject during the methylphenidate session), with about one-third of these (13% of the total) reporting that this dysphoria dominated the entire session. These negative effects were reported to be easily managed by the researchers and did not have a lasting negative effect on the subject’s sense of well-being. Further measures at 14 months after the psilocybin experience confirmed that participants continued to attribute deep personal meaning to the experience. This research was widely covered in the major media outlets. The research team cautions that if hallucinogens are used in less well supervised settings, the possible fear or anxiety responses could lead to harmful behaviors. Further studies by this group are investigating the relationship of psilocybin dose to likelihood of mystical experience in healthy volunteers[citation needed] and whether mystical experiences in volunteers given psilocybin can help with anxiety and poor mood due to cancer.

A very small number of people are unusually sensitive to psilocybin's effects, where a normally threshold dose of around 2 mg of psilocybin can result in effects usually associated with medium and high doses. Likewise, there are some people who require relatively high doses of psilocybin to gain low-dose effects. Individual brain chemistry and metabolism plays a large role in determining a person's response to psilocybin.

Psilocybin is metabolized mostly in the liver where it becomes psilocin. It is broken down by the enzyme monoamine oxidase. MAO inhibitors have been known to sustain the effects of psilocybin for longer periods of time; people who are taking an MAOI for a medical condition or are seeking to potentiate the mushroom experience may experience highly potentiated effects.

Mental and physical tolerance to psilocybin builds and dissipates quickly. Taking psilocybin more than three or four times in a week (especially on consecutive days) can result in diminished effects. Tolerance dissipates after a few days, so frequent users often keep doses spaced five to seven days apart to avoid the effect.

In rare cases, psilocybin use can cause Hallucinogen Persisting Perception Disorder

Try to visit the site of Wikipedia to get the absolutely full decription of these mushrooms.

Good luck for you !

Kristi

Answer 4

thye afefct yuor abitliy to thnik adn wriet striahgt.

Answer 5

i've heard they can cause some like mental disorders probably something like seeing strange things or getting reality confused with what happens on the mushrooms

but thats just **** i read on above the influence website

then depression can be caused by any drug when you're dependant on it your whole life

i wouldnt worry too much just as long you dont do it like everyday you shouldnt have a problem

maybe once a week is fine

Answer 6

When ingesting shrooms, you are frying your brain. It usually only effects people for up to a week. The more often you do them (which I doubt you'll want to do them again anytime soon after) the higher the chance is of your brain scrambling. Just dont do them too often or too much at one time and you'll be fine.