How does an Enzyme know which amino acide to select?

Question

Ex: can it see, can it feel, can it smell etc.?

Answer 1

Some enzymes have charges, for example a negative charge, and the amino acid will have a positive charge. Other enzymes have little pockets that only a certain amino acid will fit into. Some enzymes have charged, hydrophobic (non-aqueous) regions that attract charged, hydrophobic acids. There are a bunch of ways they can find each other.

Answer 2

Enzymes consist of amino acids.  They form tight relationships with substrates which "fit" most easility as the the "lock and key" hypothesis.