How long does Diclofenac (Voltaren) last in the body?

Question

I was told not to take it with Zoloft. I took Zoloft this morning, although I did take 150 mg of Diclofenac yesterday, my last dose being about 5.30 pm and my first dose of Zoloft being about 9.30 am today. I know the half-life is 1.2-2 hr, but I'm not good with math, I just want to know if it was safe for me to take Zoloft when I did, and if Diclofenac was out my system by that time. Thanks

Answer 1

It takes approximately 5.5 half lives before the drug is completely out of your system. As the half life is 2 hours it would take about 11 hours (2 hours x 5.5 half lives) before diclofenac would have been out of your system,so theoretically you would have been diclofenac free by 4.30 am. So it was safe for you to take Zoloft at 9.30 am.