I'd recently watched the first few episodes of the old Star Trek show. With 4 years, 11 months, and 2 weeks remaining of the 5 year mission (Kirk's 1st episode), Capt. James T. Kirk had already lost 3 officers. 2 of them were crucial positions.
Kirk lost his version of Lt. Commander DATA, the 5th highest ranking officer on board. Trek fans would know who the top 4 were.
Capt. Kirk had also lost his version of Counselor Troi. The 1st woman crew member killed in action during Kirk's command was the ship's psychiatrist, played by Sally Kellerman. http://memory-alpha.org/en/wiki/Image:Elizabeth_Dehner.jpg
After only a few episodes, the body count was already at 8.
4 were officers and 4 were enlisted. All 3 uniform colors were represented.
How many of the 430 were left at the end? Some didn't die. There was a girl who chose to stay with Kahn. http://memory-alpha.org/en/wiki/Image:MarlaMcGivers.jpg
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