How much time does a lizard take to regenerate its tail once cut?

Question

please help me ppl this is for m y bio project

Answer 1

IT IS NATURAL , YHIS PROSESS CONTINUOS LIFE LONG .

Answer 2

Several months and the tails are usually never the same.

Answer 3

Like lizards, newts, and frogs, a zebrafish can regenerate its tail once cut  within a week.

Answer 4

depends on the lizard, some never regrow their tail (like crested geckos).

Answer 5

ABSTRACT

Impaired lymphatic drainage in human limbs causes the debilitating swelling termed

lymphoedema. In mammals, known growth factors involved in the control of lymphangiogenesis

(growth of new lymph vessels) are vascular endothelial growth factors-C and –D (VEGF-C/D).

Here we characterize a model of lymphangiogenesis in which the tail of lizards is regenerated

without becoming oedematous. Three weeks after the tail is shed (autotomy), there are a small

number of large diameter lymphatic vessels in the regenerated tail. Thereafter, the number

increases and the diameter decreases. A functional lymphatic network, as determined by

lymphoscintigraphy, is established 6 wk after autotomy. The new network differs

morphologically and functionally from that in original tails. This lymphatic regeneration is

associated with an up-regulation of a reptilian homologue of the VEGF-C/D protein family

(rVEGF-C/D), as determined by Western blot analysis using a human reactive VEGF-C

polyclonal antibody. Regenerating lizard tails are potentially useful models for studying the

molecular basis of lymphangiogenesis with a view to developing possible treatments for human

lymphoedema.

Key words: tail autotomy • tissue regeneration • vascular endothelial growth factor •

lymphoedema • lymphoscintigraphy

I mpaired lymphatic drainage in upper limbs causes the debilitating swelling termed

lymphoedema. Secondary lymphoedema is a frequent side effect of removing axillary lymph

nodes and/or adjuvant radiotherapy, which are used as treatments for breast cancer (1).

Attempts to correct lymphoedema with microsurgical anastomoses of the severed lymph vessels

have had limited success to date (2, 3). However, when composite vascularized tissues are

transferred microsurgically without reconnections of the lymphatics.

Tail autotomy is achieved in the Australian gecko lizard, Christinus marmoratus, by the active

contraction of the caudal muscles. The tail can be shed voluntarily at the fracture plane, which

bisects each vertebra (6, 7). Once the tail is lost, a new complex tail is regenerated, capable of

coordinated muscle contraction (8–11). Regeneration is initiated from the blastema, which

consists of several cell types, including fibroblasts, cells of skeletal or muscle tissue, Schwann

cells, and vascular endothelial cells (6, 12). During regeneration from the lizard blastema, each

new tissue derives from the preexisting tissue cell in the stump (6). These cells undergo dedifferentiation,

reentry into the cell cycle, and then rapid proliferation (12, 13). Limbregenerating

models are used to study blastema formation and the biochemical regulation of

tissue regeneration in vitro (12, 14). However, the functional events or cellular morphology,

which characterizes lymphangiogenesis during limb/tail regeneration, have never been studied.

Moreover, lymphatic endothelial cells have not been identified in the developing blastema.

Although it is unclear whether the original lymphatic vessels are restored in a regenerating lizard

tail, the tail never appears lymphedematous. Therefore, the reactivation of mechanisms for

draining tissue fluids, either by creating new lymphatic vessels or extending existing vessels, is a

crucial component of the tail regeneration process.

Need more information:

http://www.fasebj.org/cgi/reprint/02-057...