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Nondisjunction occurred to produce a child with x*x from normal male and female parents. In order to determine in which parent the nondisjunction event occurred, DNA fingerprinting was performed. The female has the following genotype: XA Xa, where the A/a refers to which allele she has on her X chromosome. The Father’s genotype is XA Y. The child’s genotype was determined to be XA XA Xa . There are 2 different ways that this child could have received this genotype via nondisjunction of one of the parents.

List BOTH correct answers to this question: In which parent did nondisjunction occur and during which round of meiosis did it occur?

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  1. Because the kids DNA is XAXAXa the disjunction must have happened in mom's gamete because she is the parent who has an Xa allele.


  2. The nondisjunction event could have occurred in either:

    1) the mother, during meiosis I of oogenesis (i.e. the development of a primary oocyte to a secondary oocyte).  This would produce a gamete (ovum) with XA/Xa.  If this gamete is fertilized by a sperm with an XA chromosome from the father, the resulting child would be XA/XA/Xa.

    2) the father, during meiosis II of spermatogenesis (i.e. the development of a secondary spermatocyte to a spermatid).  This would produce a gamete (spermatozoa) with XA/XA.  If this gamete is used to fertilize an ovum with an Xa chromosome from the mother, the resulting child would be XA/XA/Xa.

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