In royalty, what does it mean when they say "Had issue" or "No issue?"?

Question

For example:

Princess Henrietta Maria

Married Prince x*x. Had issue.

Answer 1

I think had issue means 'had a problem with' and no issue means 'no children'.

Answer 2

it means they had children.

Answer 3

It means "had children."

Answer 4

Children, "Had issue" means she or He had a kid. No issue no kids

Answer 5

Had issue=children

No issue=no children

Answer 6

Issue is another way of saying that they had children.  No issue would therefore mean that they had no known children.

Answer 7

Issue means children

Answer 8

Had Issue means the royal married couple had children, and No Issue means the royal married did not have any children either through miscarriage or never conceieved.

If a royal figure did not produce any offpspring, usually will be written as such "Prince/Princess X died without issue."

Answer 9

issue are children