In the activation of a fatty acid, energy from the hydrolysis of ATP is used to?

Question

a. form a double bond in an oxidation reaction.

b. join the fatty acid to CoA.

c. oxidize the hydroxyl group on the β-carbon.

d. cause a unit of acetyl CoA to separate from the fatty acid chain.

e. add a molecule of water across a double bond to give a hydroxyl group on the β-carbon.

is it B?

Answer 1

b)

Answer 2

The enzyme complex called fatty acyl CoA synthetase converts fatty acids to their CoA thioesters by using ATP

( answer b ) The ATP is converted first to AMP and pyrophosphate the AMP makes a transient ester with the fatty acid which then is attacked by the strong nucleophile CoASH forming the CoA thioester. The pyrophosphate is hydrolyzed by pyrophosphatase to drive the eraction to completion. The hydrolysis of pyrophosphate is energetically equivalent to hydrolysing two moles of ATP to ADP.