Irreversible nerve damage has been reported in people taking large doses of? vitamin B12 or B6?

Question

Irreversible nerve damage has been reported in people taking large doses of? vitamin B12 or B6?

Answer 1

Vitamin B6 (pyridoxine), although technically, the effects are reversible.

Taking high doses may build up un-phosphorylated levels of vitamin, which act as an anti-metabolite relative to the smaller levels of activated vitamin. This is just a hypothesis, but I can't seem to think of any other plausible reason. Research is ongoing.

Answer 2

Really?

How large of a dose?

They are water soluble, so how can this be?

What report?

Very interesting!