Is 5-bromouracil mutagenic because its a base analog?

Question

Is 5-bromouracil mutagenic because its a base analog?

Answer 1

yes

Answer 2

the answer is yes.this happens because 5BU can substitute U at the time of replication of DNA.but intrestingly,the keto form of 5BU binds with A,but the enol form binds with C.tautomerism goes on n if at the time of replication,5BU is in the enol form it binds to C.therefore after sm reps A:T changes to C:G.thus mutation is caused. For more info check this out   http://www.springerlink.com/index/J67257...