Is Gravol (dimenhydrinate) mediated by a G-coupled receptor?

Question

Is tolerance an issue, then, with daily, chronic administration?

Thanx for your help with this everyone :-)

Huggz :-) :-)

Answer 1

The fact of the matter is that they still don't complete know how dimenhyrinate works, but if it is via the histamine receptor(s), then a GPCR would be involved.  The issue of tolerance/addiction, etc. cannot be determined by whether or not you have a GPCR.  Take, for example, the nicotinic receptor, which is NOT a GPCR, yet one can easily devolop an addiction and a tolerance to nicotine.

Answer 2

The Benedryl (H1-Antagonist) is.

EDIT: Thanks K.

EDIT: Simonize, Doesn't the CNS-Type Nicotine Receptor, Act (Initially) Through a GPCR?  The Point is that the (GPCR) Receptor Activity is Down-Regulated By the DNA (Arrestins).  Now, About Tolerance, I'm Open to the Idea that Several Things Are At Work, Take Ethanol for Example.

EDIT: K, Diphenhydramine is the H1-Antagonist, the Other Component of Gravol is Theophylline.

http://en.wikipedia.org/wiki/Dramamine

Answer 3

It seems to be a GTP-binding protein coupled receptor.

I would imagine that some tolerance will occur with chronic use./abuse.