Question:

Is it possible to convert hydroxamic acid to (NH-OH) to acetamide (NH2)?

by Guest32965  |  earlier

0 LIKES UnLike

Is it possible to convert the NH-OH group in 2-benzhydrylsulfinylethane hydroxamic acid aka "Adrafinil" to Benzhydrylsulphinyl acetamide aka "Modafinil", swapping the NH-OH for NH2? If so, how would one go about it?

 Tags:

   Report

2 ANSWERS


  1. A Google search on "reduction of hydroxamic acids" turned up an article called "Reduction of hydroxamic acids to the corresponding amides catalyzed by rabbit blood". This could be a good starting point...


  2. You would hydrogenate it:

    -NH-OH +H2 -> -NH2 + H2O

    What conditions or catalyst this might require, I have no idea. There is also the question of what else would happen to what is a complex molecule..........

Question Stats

Latest activity: earlier.
This question has 2 answers.

BECOME A GUIDE

Share your knowledge and help people by answering questions.