Is it safe defragment my c drive (xp) through vista (d drive)

Question

I'm using xp on c drive and vista on d drive. i want to know that is it safe to defragement my c drive through vista or defragment my d drive through xp.

Answer 1

In short, Yes.

In long, both operating systems run on the same type of file system. So they will both handle it in the same manner.