Is it safe to take 150mg of Wellbutrin XL and 60mg of Cymbalta together? ?

Question

(150mg Bupropion hydrochloride & 60mg duloxetine HCI)

If prescribed by a doctor? I'm just researching a prescription to see what others have to say.

Answer 1

Firstly, you should trust and listen your doctor if he gives you some kind of specific directions, because he more than likely has a very good reason to do so. Secondly, the only interactions Wellbutrin has is with carbamazepine, cimetidine, phenytoin, and phenobarbital, (decreasing their healing effect), as well as with levodopa (increasing its adverse effects). As for Cymbalta -- it has many many interactions with alcohol, drugs, and a few herbal remedies, but Wellbutrin is not one of them. So, trust me when I say you should be just fine.

Answer 2

The chemical make of the two medications are different.

This might confuse you but please hang in with me.

Wellbutrin is of the aminoketone class.

Cymbalta is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI).

These are two different classes of antidepressants.

Ok - if you are worried about the doses. Cymbalta is proven safe for doses up to 120mg. Wellbutrin XL is proven safe up to 450 mg.

There are many times that doctors will prescribe two antidepressants at the same time. The reasons are numerous. Need of more antidepressant effect, need of another uptake receptor medication, need to treat another issue, this list could go on almost endlessly.

You doctor is ok in prescribing the two together. Chemically there is no interaction, there is no know side effects of combining the two, they do not target the same receptors in the brain.