Question:

Is the sigma subunit bound to DNA polymerase delta (δ)?

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My notes say it's coupled to RNA polymerase alpha to start transcription, etc in prokaryotes, but on a take home test the question asks:

"A mutation in the sigma subunit of DNA polymerase δ causes it to remain tightly bound to the holoenzyme at all times." (Then we say what would happen in the scenario.)

Is the DNA pol. δ what part of the sigma subunit is part of? (Is it part of DNA pol, but "helps out" RNA pol.?) And I thought that DNA polymerase δ was specific to only prokaryotes (and DNA pol II was it's eukaryotic equivalent)....how is it in a bacterium/prokaryote then? I have a feeling she may have messed up what she told us in class, but unfortunately it's not in the book. I'm trying to figure out if it's a trick question or if that's how it was supposed to be.

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  1. I think it  is a misprint, and should be RNA polymerase. You might answer the question and make a note that you have assumed it is a typo. Better yet, contact your teacher for clarification of what she meant.


  2. sigma subunit is bound to rna polymerase and not to dna polymerase. It guides the enzyme to the promoter sequence while transcription

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