This is obviously more unrealistic now that Sarah Palin has been nominated for the Vice Presidency. But if McCain wins, and he genuinely wants to form the best cabinet possible, than Hillary Clinton should seriously be considered for Secretary of State.
If Obama is elected, I would hope that he would also seriously consider her. There are very few, if any, politicians that have as close a relationship with world leaders as Hillary Clinton.
As for the matter as to whether or not Hillary Clinton would accept a Cabinet position, it's clear that this would be an enormous benefit to her. She is a close friend of McCain and is currently sending subtle signals to her supporters to vote for her friend from Arizona. And this would only help her chances when 2012 comes around.
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