Mechanism of action of combizar?

Question

all about combizar

Answer 1

suggest that you google into "pharmacology of Combizar" its a High Blood Pressure pill that has a combination drug with HydroChlorthiazide. This is a strong diuretic. Well studied. If you take this you should instead use a postassium sparing diuretic such as Spironolactone. Combizar is called an Angiotensin2 inhibitor. It is basically controls High Blood Pressure.

Answer 2

Indications:

Treatment of hypertension; for patients in whom combination therapy is appropriate

-This drug consists of 2 active ingredients, Losartan potasium + Hydrochlorothiazide.

Losartan potasium is the main component and Hydrochlorothiazide acts as adjuvant diuretic to increase efficacy.

-Mechanism of Losartan potasium :

a selective, competitive Angiotensin II receptor type 1 (AT1) receptor antagonist, simply it inhibits indirectly some substances occur naturally in ur body that are responsible for body water retention. Thus by decreasing body water volume

-----> decreasing blood volume----> lowering blood pressure.

-Mechanism of Hydrochlorothiazide :

acting on the kidneys to reduce sodium (Na) reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen of the kidneys, causing less water to be reabsorbed by the collecting ducts. This leads to increased urinary output----->decreasing body water volume -----> decreasing blood volume----> lowering blood pressure.

Dosage and Administration

Usual Initial and Maintenance Adult Dose: 1 tablet of Losartan 50mg + HCTZ 12.5mg FDC once daily.

    * For patients who do not respond adequately, adjust to a maximum dose of: 1 tablet of Losartan 100 mg + HCTZ 25 mg FDC daily or, 2 tablets of Losartan 50 mg + HCTZ 12.5 mg FDC daily

    * In general, the antihypertensive effect is attained within 3 weeks after initiation of therapy.

Contraindications

    * Hypersensitivity to any component of the product

    * Hypersensitivity to sulfonamide-derived drugs

    * Pregnancy

    * Patients with anuria

Precautions

    * Do not initiate use of losartan-HCTZ FDC in patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics).

    * Losartan-HCTZ FDC is not recommended for patients with severe renal impairment (creatinine clearance < 30 mL/min) or patients with hepatic impairment

    * Based on pharmacokinetic data demonstrating significantly increased plasma concentrations of losartan in cirrhotic patients, a lower dose should be considered for patients with a history of hepatic impairment. Hence, losartan-HCTZ FDC is not recommended for patients who require dose titration with losartan.

    * Losartan may increase blood urea and serum creatinine in patients with bilateral renal artery stenosis or stenosis of the artery to a solitary kidney. These changes in renal function may be reversible upon discontinuation of therapy.

    * Use in Nursing Women: It is not known whether losartan is excreted in human milk. HCTZ appears in human milk. Because of the potential for adverse effects on the nursing infant, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother