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Question

Our homework is to do research and see how 1 type of medication can be harmful or dangerous to a person if mixed with a differnt type of medication , iv decided you use my dads medication for my homework , he takes chlorpromazine and procyclidine so what type of medication would be a harmfull mix if mixed with either of those 2 ?

Answer 1

For chlorpromazine and procyclidine check below links and scroll down to "drug interactions".

For any other drug, just go on htp://drugs.com, type in the drug brand name or active substance name, then choose "for professionals" and scroll down to find "drug interactions".

Answer 2

The following medicines may interact with Chlorpromazine hydrochloride:

    * adrenaline

    * astemizole

    * bromocriptine

    * cimetidine

    * guanethidine

    * levodopa

    * lisuride

    * lithium

    * methyldopa

    * metirosine

    * pergolide

    * phenylpropanolamine

    * pimozide

    * propranolol

    * sotalol

    * terfenadine

    * tetrabenazine

    * trazodone

The following types of medicine may interact with Chlorpromazine hydrochloride:

    * ACE inhibitors

    * adrenergic blocking agents

    * anaesthetics

    * antacids

    * anticholinergic agents

    * antiepileptics

    * antihypertensives

    * antimalarials

    * anxiolytics

    * barbiturates

    * beta-blockers

    * calcium channel blockers

    * hypnotics

    * hypoglycaemics

    * medicines that prolong QTc interval

    * medicines which depress the CNS

    * narcotic analgesics

    * sedatives

    * sympathomimetics

    * tricyclic antidepressants

procyclidine

  

  *  amantadine

    * antihistamines, eg brompheniramine, chlorphenamine

    * antispasmodics, eg hyoscine

    * antipsychotics, eg chlorpromazine, clozapine

    * certain antisickness medicines, eg promethazine, prochlorperazine, meclozine, cyclizine

    * certain medicines for abnormal heartbeats (antiarrhythmics), eg disopyramide, propafenone

    * MAOI antidepressants, eg phenelzine

    * medicines for urinary incontinence, eg oxybutynin, flavoxate, tolterodine, propiverine, trospium

    * memantine

    * muscle relaxants, eg baclofen

    * nefopam

    * other anticholinergics, eg trihexyphenidyl, orphenadrine

    * tricyclic or related antidepressants, eg amitriptyline, maprotiline.

This medicine has an opposite effect to cholinergic medicines, which work by increasing the activity of acetylcholine. If this medicine is used in combination with medicines that have cholinergic effects, the medicines may oppose each others effects, making one or both less effective. Medicines with cholinergic effects include the following:

    * medicines for myaesthenia gravis, eg neostigmine, edrophonium, distigmine, pyridostigmine

    * medicines for Alzheimer's disease, eg galantamine, donepezil, rivastigmine

    * tacrine.

Procyclidine can reduce the motility of the gut and may therefore reduce the absorption of certain other medicines taken by mouth, for example levodopa (L-dopa) for Parkinson's disease and the antifungal medicine ketoconazole. If you are taking levodopa and start taking this medicine as well, let your doctor know if your levodopa seems to be less effective.

Procyclidine may reduce the effects of the following medicines on the gut:

    * cisapride

    * domperidone

    * metoclopramide.

The antidepressant paroxetine may increase the blood level of procyclidine and this could increase the chance of side effects. If you start taking paroxetine with procyclidine and you get new or increased side effects, such as blurred vision, dry mouth, constipation or difficulty passing urine, you should let your doctor know. Your dose of procyclidine may need to be reduced.

If you experience a dry mouth as a side effect of this medicine you may find that medicines that are designed to dissolve and be absorbed from under the tongue, eg sublingual glyceryl trinitrate (GTN) tablets, become less effective. This is because the tablets do not dissolve properly in a dry mouth. To resolve this, drink a mouthful of water before taking sublingual tablets.

Answer 3

Hey!!  I have got a list of drugs that should not be used in combination with Chlorpromazine:

Before taking this medication, tell your doctor if you are taking any of the following drugs:

antacids. Take antacids at least 2 hours before or 2 hours after taking a dose of chlorpromazine. They will decrease the effectiveness of chlorpromazine.

alcohol; over-the-counter cough, cold, or allergy medications; sleep aids; antidepressants; muscle relaxants; barbiturates; and seizure medications. All of these medications will increase the side of effects of chlorpromazine-- especially drowsiness and dizziness.

blood pressure medications such as propranolol (Inderal), methyldopa (Aldomet), and clonidine (Catapres). These drugs may cause dizziness and fainting if used with chlorpromazine.

anticoagulants such as warfarin (Coumadin). Chlorpromazine may decrease the effectiveness of these medications, and blood clotting could result.

phenytoin (Dilantin). Chlorpromazine may increase the effectiveness of phenytoin and cause side effects. You may need smaller doses of phenytoin.

I have also provided you with the website in case you want to check for yourself.  Hope it helps.  Good luck with your assignment!!