Production of AAT in Dolly's milk?

Question

I was reading the notes given to me by the lecturer. It is stated that alpha-1-antitrypsin could be found in Dolly's milk. I am just wondering will we as human obtain the protein from Dolly's milk if we were to drink it. That is because as far as I know, if the milk(containing AAT protein) gets into our stomach, it gets digested and nothing will happen. But why do people still produce recombinant proteins in animals' milk? Or do they purify the milk to obtain the protein? Thanks.

Answer 1

The protein (A1AT)is purified from the milk.  Used as follows - (Inhale or inject)

Aerosolized augmented A1AT therapy is under study. This involves inhaling purified human A1AT into the lungs and trapping the A1AT into the lower respiratory tract. This method proves more successful than intravenous augmented A1AT therapy because intravenous use of A1AT results in only 10%-15% of the A1AT reaching the lower respiratory tract, whereas 25%-45% of A1AT can reach the lower respiratory tract through inhalation[