Prozac and Oxycotton?

Question

How will these two interact?

Answer 1

Your stomach will hurt & you will probably puke (depending on the oxy dosage).

Answer 2

one works  for pain one works for depression..shouldn't be any interactions

Answer 3

From Drugs.com:

fluoxetine and oxycodone (Moderate Drug-Drug)

MONITOR: A case report suggests that use of serotonin reuptake inhibitors with oxycodone may potentiate the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors. However, unlike other analgesics such as phenylpiperidine opioids (e.g., meperidine) and tramadol, oxycodone is not known to possess serotonergic activity and has not previously been associated with the serotonin syndrome. The report describes a bone marrow transplant patient who developed severe tremors and visual hallucinations after he dramatically increased his dosage of oxycodone while on a stable dosage of sertraline and cyclosporine. Discontinuation of cyclosporine did not completely resolve his hallucinations and had no effect on the tremors after 72 hours, which led to consideration of a possible sertraline-oxycodone interaction. The patient's symptoms resolved after sertraline was withheld and cyproheptadine (a central serotonin antagonist) administered.

MANAGEMENT: Until further data are available, caution is advised if serotonin reuptake inhibitors is coadministered with oxycodone, particularly in complicated patients such as transplant patients who are also receiving cyclosporine. Close monitoring is recommended for signs and symptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension, and tachycardia. Particular caution is advised when increasing the dosages of these agents.

Answer 4

Okay, here's an answer that's not "cut and paste":

Prozac (fluoxetine) and oxycontin (oxycodone) do not interact in any major way. Prozac affects the serotonin (a neurotransmitter) balance in the brains. Oxycontin mainly affects the pain transmission in your spinal cord. There is no evidence of shared metabolic pathways, so the presence of one is not going to affect the efficacy of the other.

One of the *possible* side effects of Prozac is serotonin syndrome. To date, there has been one case where a person may have had serotonin syndrome while they were taking Oxycontin, but the doctors were unable to definitively connect the two medications.

Just in case, some symptoms you might want to watch out for are:  irritability, altered consciousness, confusion, difficulty standing or moving, abdominal cramping, hot flashes, shivering, large pupils, sweating, and fast heart rate.