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Question for toxicologists and pharmacologists?

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do you know how barbiturates in high doses directly depress myocardial contractility ?

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  1. This would be a good question for an anesthesiologist... So I asked a couple I know...

    Ganglion-type Nicotinic acetylcholine receptors are inhibited by barbiturates. The inhibition causes the myocardial depression.

    Hope this helps!

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