Pathologically and biologically...?

Question

how does addiction to heroin develop?

Answer 1

Your brain wants more and more. Kinda like s*x after you have tried it, you want more and more. Your receptors in you basal ganglia gets addicted and then your pyramidal cells get destroyed and are fewer in number. It blocks neurotransmitters from getting into the synaptic cleft.

Answer 2

As a pain killer, it fools your body into not making it's natural drug called dopamine. Dopamine keeps your nerve cells from sending all possible feelings to the brain. Once your body stops making dopamine, you have to keep taking more and more of the heroin to make up for it. Everything is cool until you do not get anymore heroine and your body has nothing. Then, every nerve cell goes ballistic and transmits to the brain every sensation you can think of. This is called withdrawal. You will go through heck until your body picks up the dopamine manufacture again.