Question:

Synthesis of aspirin?

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can anyone give me links regarding with these topic, I will be submitting a full report with this matter. all helps are appreciated. thanks

these are the main things to consider:

1. preparationof acetylsalicylic acid

2. recrystallization of aspirin

3. characterization (i don't get this one)

4. main concept of organic synthesis

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  1. characterization of a compound is basically getting together all the info that can be used to define the molecule, or prove that it really is what you were hoping to make. It is kind of like fingerprinting.

    Usually the following are found out and anyone else who makes it can, for example, run an NMR spectra and get the same results,

    You can use the info to confirm you have the right product. If you do a melting point, and get the wrong temp you might start to think, have I actually made asprin?

    Some examples are

    Uv absorbance (what characteristic wavelengths does it absorb)

    Infra red spectra

    NMR spectroscopy

    Mass spectroscopy

    Melting point

    boiling point


  2. The synthesis of aspirin is classified as an esterification reaction, where the alcohol group from the salicylic acid reacts with an acid derivative (acetic anhydride), yielding aspirin and acetic acid as a byproduct. Small amounts of sulfuric acid are often used as a catalyst. This method is commonly employed in undergraduate teaching labs.[44]



    Formulations containing high concentrations of aspirin often smell like vinegar.[45] This is because aspirin can decompose in moist conditions, yielding salicylic acid and acetic acid.[46]

    The acid dissociation constant (pKa) for acetylsalicylic acid is 3.5 at 25 °C.[47]

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