What antidote can you use for organophosphate poisoning?

Question

What antidote can you use for organophosphate poisoning?

Answer 1

Atropine, as much as necessary to counter the symptoms.

Answer 2

Matrix is right. So many people have taken ACLS courses, in which the "maximum" dose of 3 mg is drilled into them, that it's often a shock to them when they see their first case of serious organophosphate poisoning, where massive doses of atropine are the rule.

I wouldn't worry too much about 2-PAM, despite the meta-analyses: the mixture of classic organophosphates and carbamates in the studies makes for a confounding variable that can't be teased out easily.

Answer 3

Atropine can be used as an antidote in conjunction with pralidoxime, though the use of "-oximes" has been found to be of no benefit, or possibly harmful, in at least two meta-analyses. Atropine blocks the parasympathetic nervous system, both vagal effects on the heart.

Wishing You All The Best !