What are the 13 factors responsible for blood clotting??

Question

i know that one of them is presence of ca++

please tell me the remaining

thanks!

Answer 1

I (fibrinogen) Forms clot (fibrin)

II (prothrombin) Its active form (IIa) activates I, V, VIII, XI, XIII, protein C, platelets

Tissue factor Co-factor of VIIa (formerly known as factor III)

Calcium Required for coagulation factors to bind to phospholipid (formerly known as factor IV)

V (proaccelerin, labile factor) Co-factor of X with which it forms the prothrombinase complex

VI Unassigned – old name of Factor Va

VII (stable factor) Activates IX, X

VIII (antihemophilic factor) Co-factor of IX with which it forms the tenase complex

IX (Christmas factor) Activates X: forms tenase complex with factor VIII

X (Stuart-Prower factor) Activates II: forms prothrombinase complex with factor V

XI (plasma thromboplastin antecedent) Activates IX

XII (Hageman factor) Activates factor XI and prekallikrein

XIII (fibrin-stabilizing factor) Crosslinks fibrin

von Willebrand factor Binds to VIII, mediates platelet adhesion

prekallikrein Activates XII and prekallikrein; cleaves HMWK

high molecular weight kininogen (HMWK) Supports reciprocal activation of XII, XI, and prekallikrein

fibronectin Mediates cell adhesion

antithrombin III Inhibits IIa, Xa, and other proteases;

heparin cofactor II Inhibits IIa, cofactor for heparin and dermatan sulfate ("minor antithrombin")

protein C Inactivates Va and VIIIa

protein S Cofactor for activated protein C (APC, inactive when bound to C4b-binding protein)

protein Z Mediates thrombin adhesion to phospholipids and stimulates degradation of factor X by ZPI

Protein Z-related protease inhibitor (ZPI) Degrades factors X (in presence of protein Z) and XI (independently)

plasminogen Converts to plasmin, lyses fibrin and other proteins

alpha 2-antiplasmin Inhibits plasmin

tissue plasminogen activator (tPA) Activates plasminogen

urokinase Activates plasminogen

plasminogen activator inhibitor-1 (PAI1) Inactivates tPA & urokinase (endothelial PAI)

plasminogen activator inhibitor-2 (PAI2) Inactivates tPA & urokinase (placental PAI)

cancer procoagulant Pathological factor X activator linked to thrombosis in cancer

Answer 2

1.I (fibrinogen)

Forms clot (fibrin)

2.II (prothrombin)

Its active form (IIa) activates I, V, VIII, XI, XIII, protein C, platelets

3.Tissue factor

Co-factor of VIIa (formerly known as factor III)

4.Calcium

Required for coagulation factors to bind to phospholipid (formerly known as factor IV)

5.V (proaccelerin, labile factor)

Co-factor of X with which it forms the prothrombinase complex

6.VI

Unassigned – old name of Factor Va

7.VII (stable factor)

Activates IX, X

8.VIII (antihemophilic factor)

Co-factor of IX with which it forms the tenase complex

9.IX (Christmas factor)

Activates X: forms tenase complex with factor VIII

10.X (Stuart-Prower factor)

Activates II: forms prothrombinase complex with factor V

11.XI (plasma thromboplastin antecedent)

Activates IX

12.XII (Hageman factor)

Activates factor XI and prekallikrein

13.XIII (fibrin-stabilizing factor)

Crosslinks fibrin