What are the rarest human haplotypes?

Question

What are the rarest human haplotypes?

Answer 1

The rarest haplotypes would be those present in the most genetically isolated populations - that is, those that have evolved for the longest time on their own. I'm not sure what population that might be. Australian aborigines may have a good shot, here, since they've probably spent ~40,000 years on their own, but then again some African population like the Khoisan might have been isolated for even longer (I don't think this is true for the Khoisan, but it might be).