What did isabella d'este do?

Question

what was she mainly known for?

Answer 1

She works at the local McDonalds and noone places cheese on a burger with anywhere near the class and style than  does Isabella.

Answer 2

Isabella d'Este (18 May 1474 - 13 February 1539, death at 65 years old) was marchesa of Mantua and one of the leading women of the Italian Renaissance and a major cultural and political figure.

After the death of her husband, Isabella ruled Mantua as regent for her son, Frederick. She began to play an important role in Italian politics, steadily advancing Mantua's position. Her many important accomplishments include advancing Mantua to a Duchy and also obtaining a cardinalate for her younger son. She also showed great diplomatic and political skill in her negotiations with Cesare Borgia, who had dispossessed Guidobaldo da Montefeltro, duke of Urbino, the husband of her sister-in-law and intimate friend Elisabetta Gonzaga.