What is a lethal dose of Temazepam, is it more effective taking it with Diazepam?

Question

This is not a suicide question, so please no christians advising not to do it or no stupid answers, just factual please. This is a research question. So once again, if you have nothing factual to answer don't bother. Thanks in advance.

Answer 1

Manifestations of acute overdosage of Temazepam can be expected to reflect the CNS effects of the drug and include somnolence, confusion, and coma, with reduced or absent reflexes, respiratory depression, and hypotension. The oral LD50 of Temazepam was 1963 mg/kg in mice, 1833 mg/kg in rats, and >2400 mg/kg in rabbits.

Interactions between your selected drugs

Diazepam and Temazepam (Moderate Drug-Drug)

MONITOR: Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients.

MANAGEMENT: During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities

Good Luck !